Estrogen, Progesterone and Human epidermal growth factor receptor - 2 in malignant breast lesions: A 5 year study in a tertiary care hospital of Karnataka

Background and Objective: Breast cancer is the second leading cause of cancer related death in India. Immnuohistochemical study helps to carry out a better management of the disease and to determine the prognosis. This study was conducted to correlate histopathology of the breast tumours, with reference to tumour grade, and common immnuohistochemical markers like Estrogen receptor (ER), Progesterone receptor (PR) and Human epidermal growth factor receptor-2 (HER2) status. Methods: The present study was conducted in the Pathology department of SSIMS&RC, Davangere, from January 2009 to December 2013. Thirty patients with breast carcinoma underwent mastectomy were included in this study. Those specimens were evaluated both for histopathologically and immunohistochemically by Allred scoring for ER, PR, HER-2 markers. All the experimental data were judged for correlations with histopathological features of specimens and immnuohistochemical presentation of the specimens. Results: Majority of the cases founding 41-60 years of age group with Invasive ductal carcinoma Grade 3. ER, PR, Her-2 positivity were found in 56.67%, 50%, and 20% of specimens respectively. Luminal A wasthe most common subtype. Three triple positive IDC cases were seen, suggesting superior response to hormonal therapy. Conclusion: There is geographical and genetic variation among local population groups compared to other Indians. Cost effective immunohistochemistry-based classification on ER, PR, and HER-2 status incorporating in the histopathological evaluation of breast carcinoma assist in better therapeutic management and prognostication.