Lipid profile in Diabetes Mellitus

Diabetes mellitus is the most common metabolic disorder affecting the people all over the world. Diabetes mellitus has been known to be associated with lipid disorders and cardiovascular complications. This study is planned to assess the lipaemic changes in diabetes mellitus patients attending the out-patient department of medicine department in HSK Hospital and Research Centre. Total Cholesterol(TC), Triglycerides(TG), LDL Cholesterol(LDL-C), HDL Cholesterol (HDL-C) levels were studied in serum of diabetes patients. This is a case control study which included 76 patients of diabetes as cases and 50controls of the same age group and sex. All the samples were taken from subjects who fasted for at least 12 hours before the blood collection. The parameters were determined by manual method using spectrophotometer by liquid chemistry. The Triglycerides, Total cholesterol, LDL Cholesterol were higher in cases as compared to controls in both IDDM and NIDDM. The HDL-C was lower in NIDDM subjects who were on sulfonylurea or biguanides and was not significantly altered in IDDM patients on insulin. There was significant correlation between FBS and TC, TG, LDL-C and HDL-C in NIDDM patients. TC, TG, LDL-C showed significant correlation in IDDM subjects.