Serum Uric Acid on Metabolic Syndrome - A Case Control Study

The metabolic syndrome is a widely prevalent and multi-factorial disorder that presents in a distinct, heterogeneous phenotype.The clinical relevance of the metabolic syndrome is related to its role in the development of cardiovascular disease. The major features of the Metabolic Syndrome include central obesity, Hyper-triglyceridemia, low high-density lipoprotein (HDL) cholesterol, Hyperglycemia and Hypertension. Mean serum uric acid levels vary with variable components of metabolic syndrome. There is a direct linear relationship between serum uric acid level and number of metabolic syndrome patients. Increased levels of serum uric acid should be considered as an important marker in patients with metabolic syndrome and Hyperuricemia is an associated abnormality that should be considered in those with metabolic syndrome. Aim & Objective of study is to evaluate the association between serum uric acid and metabolic syndrome and correlation of uric acid levels with various components of metabolic syndrome. Type of study was conducted as a case control study. The patients included in the study group were adults of either sex having metabolic syndrome. Cases were taken as 100 and control as 50. Study Period: August 2012 to July 2013 Material and Method: The study conducted in department of Medicine, Santosh Medical College, Ghaziabad, Uttar Pradesh.The study was approved by the departmental scientific review board and ethics committee of SantoshMedical College & Hospitals. A written informed consent was taken from the patients inducted into the study. A copy of patient information sheet was also given to the patient. Result: It is seen when mean serum uric acid of triglycerides, HDL, Fasting plasma glucose, Blood Pressure and Obesity was compared to mean of uric acid of controls, results was significant. Conclusion: Hyperuricemia should be considered as a component of metabolic syndrome and risk factor for cardiovascular diseases.