Formulation and Evaluation of Immediate Release Tablets of Fexofenadine Hydrochloride
Journal: Journal of Pharmacy Research (Vol.10, No. 2)Publication Date: 2016-02-29
Authors : Gholve Sachin; Barhate Ganesh; Todkar; Sharad; Suryawanshi Ranjana; Bhusnure Omprakash;
Page : 90-96
Keywords : Allergic rhinitis; Crospovidone; Croscarmellose sodium.;
Abstract
The present research work is to develop immediate release tablets of Fexofenadine hydrochloride. The rate of dissolution and bioavailability of the Fexofenadine HCL has been increased by using superdisintegrants in its immediate release tablets. Direct compression method was adapted to prepare the tablets by using Sodium lauryl sulphate, microcrystalline cellulose as filler, crospovidone and sodium starch glycolate as superdisintegrant in different concentration (2-8%). Tablets were prepared and evaluated pre and post compressional parameters. In-Vitro Disintegration study shows that as there is increase in disintegration time with increase in concentration of sodium starch glycolate while there is decrease in disintegration time with increase in the level of crospovidone. The results indicate that the selected batch of tablet formulation containing crospovidone provides disintegration time between 3-6 minutes with sufficient crushing strength and accepted friability. It was concluded that immediate release tablet for Fexofenadine hydrochloride can be formulated for fast treatment of allergic rhinitis.
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