PREPARING AND EVALUATING SUSTAINED-RELEASE (SR) MATRIX TABLETS OF ALBENDAZOLE USING DIFFERENT POLYMERS

In the present investigation an attempt has been made to study the formulation and evaluation of sustained release tablets of Albendazole using okra gum and starch. The matrix tablets were formulated using different polymer concentrations of okra gum. The developed formulations of tablets were evaluated for pre-compression and postcompression parameters. The results of pre-compression parameters like bulk density, tapped density, Carr’s index and Hausner’s ratio were found to be within the limits indicating good flow properties of the granules. In-vitro drug release for F13 formulation was found to be 98.3% at the end of 12 hrs. With increase in gum concentration the drug release from the matrix tablets got retarded. In-vitro drug release data obtained were fitted to various release models access the possible mechanism of drug release. All the formulations showed matrix (exponential model) as a best fit model and the release mechanism was found to be anomalous (non Fickian) transport mechanism. Matrix tablets of albendazole using okra gum and starch and water as a release retardant could be employed for retardant drug release. Keywords: Okra gum, Albendazole, Sustained release tablet