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Syndrome Of Inappropriate Antidiuretic Hormone Secretion In A Patient With A Nodular Lymphocyte-Predominant Hodgkin Lymphoma. A Case Report And Review Of Literature

Journal: Journal of Hematology and Oncology Research (Vol.2, No. 1)

Publication Date:

Authors : ; ; ;

Page : 1-6

Keywords : lymphoma; vinblastine; SIADH;

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Abstract

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a known side effect of several oncology drugs, but it is rarely seen secondary to vinblastine with only a few cases reported worldwide. Herein we present a patient with nodular lymphocyte-predominant Hodgkin disease that developed a severe acute hyponatremia seven days after her first cycle of chemotherapy with R-ABVD. After fluid restriction, symptoms and concentration of blood sodium were restored. After a comprehensive review of the literature vinblastine was thought to be the cause and avoided in the second infusion of chemotherapy without recurrence of the SIADH.

Last modified: 2016-03-05 20:21:42