SYNTHESIS AND CHARACTERIZATION OF SOME NEW SUBSTITUTED FLAGYLE DERIVATIVES

Metronidazole,2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol (1). Metronidazole is one of the nitroimidazole derivatives (2) .is an antimicrobial drug that is used to treat protzoal and anaerobic bacterial infections (3) . IntravaginalMetronidazole is effective in the treatment of bacterial vaginosis .Metronidazole, as benzoyl form, could be . used as supportive suppressive and/or synergistic additive drug in treatment of africantrypanosomiasis(4) .Schiff base has been reported a new compound called imine, it has been obtained by condensation of aldehydes(aliphatic or aromatic) or ketons (aliphatic or aromatic) with primary amines(5) . Schiff bases are characterized by the ?N=CH-(imine group) which is important in elucidation the mechanism of transformation in biological system. Due to great flexibility and different structural sides, a wide range ofSchiff's bases have been synthesized and their complexities have been studied.. β-Lactam is a four member cyclic amide which is consisting of three carbon atoms and one nitrogen atom (6) . The β-lactam ring is a part of the core structure of several antibiotic families, the principal ones being the penicillin, cephalosporin, carbapenems, and monobactamswhich are, therefore, also called β-Lactam antibiotics (7) .