ANTIVIRAL PROPERTIES OF PHYTOCHEMICALS FROM TOMATO

Hepatitis D (hepatitis delta) is a disease caused by the hepatitis D virus (HDV), a small circular enveloped RNA virus. This is one of five known hepatitis viruses : A, B, C, D, and E. HDV is considered to be a sub viral because it can propagate only in th e presence of the hepatitis B virus (HBV). Transmission of HDV can occur either via simultaneous infection with HBV or superimposed on chronic hepatitis B or hepatitis B carrier state. Auto Dock is molecular modelling simulation software. It is especially effective for Protein - ligand docking. Auto Dock 4 is available under the GNU General Public License. AutoDockVina is available under the Apache license.AutoDock is one of the most cited docking software in the research community. The docking of phytochemic al betasetastirol was done with Hbc Ag using auto dock tool which is free software downloaded through Google. Β - Sitosterol is one of several phytosterols with chemical structures similar to that of cholesterol. Sitosterols are white, waxy powders with a ch aracteristic odor. They are hydrophobic and soluble in alcohols. The docking score using Auto dock for the ligand protein interaction was found to be there exist a good interaction between them. The interaction between the protein ligand complexes is visua lizing using various tool. It shows clear atomic interaction between ligand and receptor. So the 4 ligand was made to bind with these two protein invasion of metastasis. Thus binding between ligand and receptor prevents the disease. Hence, further studies can be taken up to evaluate the use of four compounds for preventing hepatitis D