Toxicological studies of Rasnairandadi Kvatha Curna

The present study was undertaken to investigate the toxicological effects of Rasnairandadi Kvatha Curna (RAS), a classical ayurvedic preparations used as an analgesic drug.Various biochemical parameters such as total protein, serum albumin, bilirubin, creatinine, and liver enzymes i.e. serum glutamic pyruvic transaminase (sGPT), serum glutamic oxaloacetic transaminase (sGOT) and alkaline phosphatase (ALP) of experimental rats were analysed after chronic administration of RAS. The total protein content showed no significant difference between the control and the RAS treated both male and female rats. Albumin content significantly increased (p<0.001) in both RAS treated male and female compared to control. There was a significant increase of sGPT (p<0.001) and sGOT (p<0.05) activities found in the plasma of RAS treated male rats compared to control. Also, ALP levels significantly (p<0.001) increased in the plasma of RAS treated male rats. On the contrary, RAS treated female rats revealed a significant decrease in the sGPT and sGOT levels in the plasma. The ALP levels in the plasma of treated female rats were also decreased but was statistically insignificant (p=0.438NS) in comparison to their corresponding control values. The level of bilirubin was decreased in male and increased in female rats and it was statistically significant (p<0.001). Overall, the results show some alterations on liver and kidney parameters of experimental rats which indicate that RAS may produce toxic effects.