THE CONTRASTIVE VALUATION OF ANGIOGENIC EFFICACY OF THE L-ARGININE AND VASCULAR ENDOTHELIAL GROWTH FACTOR FOR TENTATIVE LIMB ISCHEMIA

The tentative research was made in 24 rats, Wistar line. The microcirculation level was evaluated in Laser-Doppler flowmetry method and by immunohystochemical visualization of the vessels in the muscles. The chronic ischemia was modeling by cutting out of the femoral artery. The intramuscular introduction of VeGF and intraperitoneal introduction of L-arginine 200 mg/kg were used for treatment. The isotonic solution of NaCl was used in control group. The results were valued in 14-th day. The vessels number increased in groups treated by VeGF and L-arginine. It was statistical difference in microcirculation level between control group and group that was treated by L-arginine.