Particularity of pathogenic and principles of pathogenic therapy of edogenous intoxication in patients with acute appendicitisrelated peritonitis

We performed the cytological analysis of impression smears, taken from the abdominal cavity of 86 patients with acute appendicitis-related peritonitis. It was detected that with the rise of the endogenous intoxication degree the number of neutrophils with intact nuclei structures decreases and the number of degenerative neutrophilic leukocytes increases that indicates the development of immunodeficiency and weakening of the organism's reactivity. Besides as a result of electrogastroenterography of the same patients during the preoperative period, we revealed the direct relation: the more serious the endogenous intoxication the more evident the paresis of gastrointestinal tract. These rates should be viewed as important diagnostic criteria to identify the degree of endogenous intoxication. The pathogenetically based antibiotic therapy for patients with acute appendicitis-related peritonitis having 3rd degree endogenous intoxication is the administration of 3rd generation cephalosporins (cephotaxim), carbopenems (imipenem), fluoroquinolones(ciprofloxacin).