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INDIVIDUAL DIFFERENCES OF TARGET ORGANS REACTION OF WISTAR RATS TO ACUTE BACTERIAL ENDOTOXICOSIS
Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.12, No. 1)Publication Date: 2011-02-26
Authors : Kosyreva A.M.; Soldatov D.I.; Vasil'eva S.G.;
Page : 26-32
Keywords : ;
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Abstract
Individual morphofunctional differences of target organs of Wistar rats to acute endotoxicosis, induced by lypopolisaccharide (LPS) administration in high dose were investigated. By cluster analysis of target organs and cytokines characteristics Wister rats were divided into two groups - with high and low production level of Th1 cytokines. In 24 hours after LPS administration hepatic dystrophic changes and lung inflammation in rats with low level of Th1 cytokines (IL-2, IF-γ) were more expressed than in rats with high level of Th1 cytokines. In 7 days individual morphofunctional differences were less expressed and mainly were found out on functional level
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