The study of anthihypoxic and antiischemic activity of phytoecdysterone

In this research it is established that the phytoecdysterone (PE) administration (per os, 5 mg/kg) for 7 and 14 days increases resistance of the nonlinear white rats to an acute hypobaric hypoxic hypoxia. PE administration for 3, 7 and 14 days increased resistance of isolated cardiomyocytes to acute total ischemia. These effects may be related to the ability of the PE (daily administration within 7 days) to increase the glycogen content in the brain, in the myocardium and in the liver, glucose ? in the brain and in the myocardium, catalase activity in the liver, glutathioneperoxidase activity in the brain and to decrease lactate levels in the brain and MDA levels in the liver