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The study of anthihypoxic and antiischemic activity of phytoecdysterone

Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.12, No. 3)

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Authors : ; ; ; ;

Page : 30-36

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In this research it is established that the phytoecdysterone (PE) administration (per os, 5 mg/kg) for 7 and 14 days increases resistance of the nonlinear white rats to an acute hypobaric hypoxic hypoxia. PE administration for 3, 7 and 14 days increased resistance of isolated cardiomyocytes to acute total ischemia. These effects may be related to the ability of the PE (daily administration within 7 days) to increase the glycogen content in the brain, in the myocardium and in the liver, glucose ? in the brain and in the myocardium, catalase activity in the liver, glutathioneperoxidase activity in the brain and to decrease lactate levels in the brain and MDA levels in the liver

Last modified: 2016-03-29 02:15:29