Red cell incompatibility due to antibody against ingredient in column matrix: a rare entity

An essential goal in transfusion medicine is that transfused blood be compatible with the patient. Several problems arise while performing pre-transfusion compatibility testing. Rarely, in vitro reactions not due to blood group antibodies are sometimes encountered which can pose difficulty in routine immunohematology work up. Though these antibodies are clinically insignificant, proper work-up is indicated, before labelling such antibodies as clinically insignificant. In the report we describe a rare case wherein the patient had an antibody against the ingredients of the matrix of column agglutination.