EFFECT OF THE DEGREE OF IMMUNOSUPPRESSION AND HIGHLY ACTIVE ANTIRETROVIRAL THERAPY ON SERUM IL-17 AND IL-10 LEVEL IN PATIENTS WITH HIV-INFECTIONJournal: I.P. Pavlov Russian Medical Biological Herald (Vol.13, No. 3)
Publication Date: 2012-09-29
We analyzed IL-17 and IL-10 serum levels in HIV-infected patients with different stage of disease, degree of immunodeficiency and treatment. We observed 70 patients with HIV infection. Among the patients studied 44 patients on antiretroviral therapy. HIV infection is marked increase in the concentration of IL-10, especially in patients with severe immunosuppression (CD4 <200 ml-1). In HIV-infected patients with severe immunosuppression, which do not receive highly active antiretroviral therapy, there is an increase of IL-10 and IL-17 in serum, which may indicate a systemic immune activation.
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