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Oral hormonal contraceptive "janine" influence on P-glycoprotein functional activity
Journal: I.P. Pavlov Russian Medical Biological Herald (Vol.13, No. 4)Publication Date: 2012-11-30
Authors : Yakusheva E.N.; Kotlyarova A.A.; Nikiforov A.A.;
Page : 65-70
Keywords : ;
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Abstract
In the research on rabbits influence of combined oral contraceptive, "Janine" on the functional activity of the protein efflux transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic analysis of marker substrate fexofenadine. It was found that administration of the drug "Janine" for 14 and 21 days, resulting in inhibition of Pgp functional activity.
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