THE INFLUENCE OF EXPERIMENTAL SUBACUTE HYPOBARIC HYPOXIA ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITYJournal: I.P. Pavlov Russian Medical Biological Herald (Vol.14, No. 1)
Publication Date: 2013-01-29
Authors : Yakusheva E.N.; Chernykh I.V.;
Page : 60-64
Keywords : ;
In a study on rabbits the effect of the experimental subacute hypobaric hypoxic hypoxia on the functional activity of ATP-dependent protein transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic of it’s marker substrate fexofenadine. It was found that 4-hour hypoxic action leads to Pgp induction.
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