ROLE OF MATRIX METALLOPROTEINASES IN THE PATHOGENESIS OF PRIMARY OPEN-ANGLE GLAUCOMA

Matrix metalloproteinases (MMPs) - a family of enzymes, which convert extracellular matrix. Proved the role of MMPs in apoptosis of retinal ganglion cells, tissues remodulition the optic nerve and the change in the form of lattice plate with POAG. MMPs are involved in violations of blood aqueous barrier and the regulation of intraocular fluid. Many papers have focused on the role of these enzymes in the filter pad with scarring antiglaucomatous operations. The study of MMPs offers the prospect of early diagnosis and targeted therapy of POAG pathogenesis.