IMPACT OF CHRONIC HEART FAILURE IN THE MANIFESTATION OF SEIZURE READINESS AND ITS ASSOCIATION WITH RESISTANCE TO HYPOXIAJournal: I.P. Pavlov Russian Medical Biological Herald (Vol.14, No. 3)
Publication Date: 2013-09-30
Chronic heart failure (CHF) modulates the activity of monoaminergic (MA-) systems and increases seizure readiness, and the severity of seizure depends on the individual resistance of the organism to oxygen deficiency. Increasing seizure readiness, and reduction of monoamines in postictal period at high and low resistance of the animals with CHF gives reason to believe that the activity of MA-ergic system may be a factor limiting the implementation of compensatory capacities in heart failure. Postictal period against the background of heart failure is characterized by the marked reduction in aminergic tone in the brain regions studied low resistance of the animals that are likely to acquire pathogenetic importance and can be the basis for the occurrence of repeated seizures.
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