PREPARATION AND STUDY OF TWO NEW SCHIFF BASES AND THE STUDY OF BIOLOGICAL EFFECTIVENESS ON INFECTED MICE BY THE PARASITE ENTAMOEBAHISTOLYTICA

In the present work two new Schiff bases are synthesized, the first from reaction of 2-hydroxy-1-naphthaldehyde with sulphamethoxazole, and the second from reaction of 4-Acetmidobenzaldehyde with 3,4-Diamino toluene. These Schiff bases were verified by some spectral data (1H-NMR , IR, and mass spectra). Stool samples were collected from people infected with maebiasis to infect laboratory mice. It has been determined LD50 for the two ligands - after dissolved dimethyl sulfoxide DMSO - and account for them safe therapeutic dose, reaching 0.14 g / kg and 0.24 g / kg, respectively. Reached the less impact to the second ligand rate about 2.9., the highest inhibiting effect of metronidazole was at a rate of 0, while in the seventh day of them , the first ligand was a compromise in effect, amounting to at a rate of 1.1.