DETERMINATION OF TOXIC AND ESSENTIAL ELEMENTS IN THE SCALP HAIR OF PATIENTS WITH TYPE 2 DIABETES

Diabetes is one of the most common chronic diseases in the word. Many factors such trace elements contributing to the pathophysiology of type II Diabetes mellitus (DM). Certain elements have been identified as essential trace elements that play an important role in the genesis and progression of such diseases like diabetes. The aim of the present investigation was to evaluate lead, cadmium, copper, zinc, iron, molybdenum, nickel, cobalt and chromium, contents in scalp hair samples of patients having diabetes mellitus type-2 from Tehran (Iran). The hair samples were collected during 2009 ? 2010, from 108 patients having diabetes mellitus type-2 age ranged (35-55), for a comparative study 250 age matched non-diabetics, healthy subjects of the same city were selected. Prior to analysis, samples were washed with 1% (w/v) sodium diethyldithiocarbamate (DDTC), 0.1M HCl, and deionized water. The hair samples were digested afterward in a mixture of HNO3, and H2O2. Concentrations of all metals were assessed by flame and graphite furnace atomic absorption spectrophotometer. The type 2 diabetes was corresponding to elevated hair Pb, Cd, Cu, Ni, Mo, Al and decreased Fe, Cr, Co and Zn