25(OH)D was Correlated with Increased Risk of Insulin Resistance, but Not Mediated by Adiponectin and hsCRP
Journal: The Indonesian Biomedical Journal (Vol.4, No. 2)Publication Date: 2012-08-01
Authors : Anggi Kartikawati; Yani Lina; Andi Wijaya;
Page : 84-92
Keywords : Central obesity; 25(OH)D; Adiponectin; hsCRP; Insulin resistance (HOMA-IR);
Abstract
BACKGROUND: Studies have shown that change of calcium and vitamin D homeostasis is associated with insulin resistance, decreased beta cell function, metabolic syndrome, glucose intolerance and diabetes. Evidence suggests that vitamin D insufficiency is inversely related to risk of metabolic disorders including type-2 Diabetes Mellitus (T2DM), although the underlying mechanisms are not yet understood. Hence, current study was conducted to investigate correlation between 25(OH)D and insulin resistance through adiponectin or High Sensitivity C-Reactive Protein (hsCRP) in centrally obese men. METHODS: This was a cross-sectional study involving 80 centrally obese men with waist circumference (WC) >90 cm and age 30-60 years. Total 25(OH)D concentration was measured by Enzyme-Linked Immunosorbent Assay (ELISA) method. Insulin resistance was calculated by HOMA model. RESULTS: This study showed there was no correlation of 25(OH)D-WC (r=0.006 and p=0.957), 25(OH)D-adiponectin (r=0.179 and p=0.111) abd 25(OH)D-hsCRP (r=-0.223 and p=0.334), but we observed statistically significant negative correlation between 25(OH)D and insulin resistance index (HOMA-IR) (r=0.461 and p=0.041). CONCLUSIONS: We conclude that low 25(OH)D concentration was significantly associated with increased risk of insulin resistance. Since the adiponectin or hsCRP was not correlated, the possible pathways need to be futher investigated.
Other Latest Articles
- Inflammation and Atherosclerosis: Current Pathogenesis
- Adipose-Derived Stem Cells for Future Regenerative System Medicine
- Association Between Cathepsin S, Cystatin C and High Sensitivity C-Reactive Protein (hsCRP) with Oxidized LDL (Ox-LDL) in Men with Central Obesity
- The Dynamic Roles of Visfatin and Obestatin Serum Concentration in Pancreatic Beta Cells Dysfunction (HOMA-beta) and Insulin Resistance (HOMA-IR) in Centrally Obese Men
- Waist Circumference was Positively Correlated with Chemerin, Retinol-Binding Protein 4 and hsCRP
Last modified: 2016-04-13 13:13:41