MMP-9 Level Comparation between Spontaneous Abortion and Normal Pregnancy
Journal: The Indonesian Biomedical Journal (Vol.4, No. 3)Publication Date: 2012-12-01
Authors : Aloysius Suryawan; Johanes C Mose; Budi Handono;
Page : 174-9
Keywords : MMP-9; Spontaneous abortion; Normal pregnancy;
Abstract
BACKGROUND: Abortion remains a problem in the obstetric care as it is one of the causes of maternal and fetal death. Bleeding or miscarriage threat in the first trimester comprises 20% to 25% of all pregnant women, and 50% of them will end as spontaneous abortion. The major cause of maternal death in abortion is hemorrhage. Some recent studies have indicated that MMP-9 is important in the process of embryo implantation into the endometrium and spontaneous abortion occurs when there is an overwhelming increase of MMP-9. This data indicate the importance of a further research to elucidate the role of MMP-9 in spontaneous abortion. METHODS: This was a cross sectional study, included 70 pregnant women with gestational age <20 weeks who came for examination and treatment at the Department of Obstetrics and Gynecology, Medical Faculty of Padjadjaran University/Hasan Sadikin Hospital, Bandung. RESULTS: There were differences in the MMP-9 levels in spontaneous abortion compared to normal pregnancy and MMP-9 had a cut-off point >1221.7 with the sensitivity of 48.6% specificity of 80%, and accuracy of 60.9%. SUMMARY: The MMP-9 level in spontaneous abortion was higher than in normal pregnancy.
Other Latest Articles
- Comparison of the Effects of Three Extract Sorts of Soybean DETAM 1 on the Total Cholesterol Level in Balb-C Male Mice
- C-Reactive Protein and Matrix Metalloproteinase-9 are Associated with Outcome of Ischemic Stroke
- Correlation between Inflammation and Fibrinolysis in Hypertensive Centrally Obese Subjects: A Study on C-Reactive Protein, Plasminogen Activator Inhibitor-1 and Thrombin Activatable Fibrinolysis Inhibitor
- The Role of Signal Transducer and Activator of Transcription 3 (STAT3) in Tumor Immunity
- Molecular Regulators of Metabolism and Cardiometabolic Disease
Last modified: 2016-04-13 13:40:04