Synthesis and microbiological activity of 8-hydroxy quinoline derivatives and related compounds

Objective: Hydrazine and substituted hydrazines have tendency to take part in substitution as well as condensation reaction. The condensation with suitable carbonyl compound gives hydrazides. These hydrazides undergo cyclization under suitable condition gives 2-nitrogen atom containing heterocyclic ring system. These compounds have pronounced antibacterial activity. 1,3,4-oxadiazole constitute a unique class of nitrogen and oxygen? containing five member heterocycle. During the last years considerable evidence has also accumulated to demonstrate the efficacy of 1,3,4-oxadiazole including antifungal, anticancer, anticonvulsant, insecticidal, anti-bacterial, anti-inflammatory? and other biological effects.Methods: Some new Quinoline derivatives were synthesized by the reaction of Quinoline, chloroethylacetate, hydrazine hydrate and substituted benzoic acid. The structures of the various synthesized compounds were characterized on the basis of elemental analysis, IR and H1NMR spectral data. These compounds were also screened for their antimicrobial and antifungal activity.Results: The synthesized compounds 1a and 3c showed effective antibacterial activity against Basillus substilis whereas 2b and 4d showed effective anti-fungal activity against Candida albicans and Aspergillus niger respectively.Conclusions: New oxadiazole derivative compounds exhibit significant antimicrobial activity.