To interdependence of violations of molecular systems of noci- and antinociceptive in pathogeny of chronic dermatosis

The article of the conducted research was a study of markers of the molecular systems of noci-/antinociceptive, in particular to content in blood of patients with psoriasis and acne of substance P and beta-endorphin. To that end there was the found out role of these mediators/modulators in forming (whether to absence) of the subjective feelings on a skin at these dermatosis, that it was attained the study of their content in blood of the proper patients by an ELISA method. Intercommunications of clinical and laboratory indexes were probed the modern methods of statistics. Revealed disproportion between an area and degree of damage of skin and severity (or by absence) of the nociceptive sensations, which correlated with findings of ELISA researches (by the substance P and beta-endorphin). The increases of level of content in blood of substance P at psoriasis and acne on a background an insignificant increase or diminishing of level beta-endorphin testify to exhaustion of scray possibilities of the systems of antistress protection. The got results dictate the necessity of their account during implementation of therapeutic and preventive measures not only for patients with psoriasis and acne but also at other damages of skin, which are observed in practice of dermatologists and cosmetologists.