Measurement of serum calcium, magnesium and phosphorus level during different phases of menstrual cycle

Introduction: The menstrual cycle is the regular natural change that occurs in the uterus and ovaries that make pregnancy possible. The cycle is required for the production of ovocytes, and for the preparation of the uterus for pregnancy. Up to 80% of women report having some symptoms during the one to two weeks prior to menstruation. Common symptoms include acne, tender breasts, bloating, feeling tired, irritability, and mood changes. Aim and objectives: The purpose of this study was to evaluate the changes in serum Calcium, Magnesium and Phosphorus levels during various phases of menstrual cycle in healthy normally menstruating female. Materials and methods: The 90 healthy female volunteer students participated as subjects in this study. The blood sample was collected three times from each subject during their menstrual, proliferative and secretory phase. Estimation of serum calcium, magnesium and phosphorus was carried out on the same day of collection of blood sample. Results: Highest level of serum calcium was seen in proliferative phase. Highest level of serum magnesium was seen in secretory phase. Study showed gradual decrease in serum phosphorus level from menstrual to proliferative phase and also from proliferative to secretory phase. Highest level of serum phosphorus was seen in menstrual phase. Conclusions: These variations could be due to the impact of the changing estrogen and progesterone secretion on the parathyroid glands.