Wound healing activity reported on leaf extract of Murraya paniculata (Linn) on albino wistar rats

Murraya paniculata (L) (Family - Rutaceae) is an evergreen shrub or occasionally a small tree, known for its pharmacological activities like anti-inflammatory, antidiabetic and stimulant and analgesic and antioxidant properties etc. The present study was aimed to assess the wound healing potential of crude methanol extract and aqueous extract of Murraya paniculata (leaf) using three types of wound models in rats as incision wound, excision wound and dead space wound. The parameters studied include rate of wound contraction and period of epithilization, collagen content in excision wound model. Tensile strength, hydroxyproline estimation and granuloma tissue weight were studied in incision and dead space wound model and assessed alongwith histopathalogical examination. The treatment of wound with the methanol and aqueous extract was performed in graded dose manner. Higher dose of methanol extract (200 mg/kg b.w.) show significant effect by decreasing period of epithilization, increasing wound contraction rate, increase in tensile strenghth, hydroxyproline content and granulation tissue weight in the wounded rats and more effective when compared with aqueous extract and control. While aqueous extract (200 mg, 100 mg/kg b.w) show more significant effect than the control. Therefore, M. Paniculata leaves accelerated wound healing activity in rats and thus supports its traditional use.