PROGNOSTIC VALUE OF BCL2 - ASSOCIATED X PROTEIN (BAX) EXPRESSION IN ADULT EGYPTIAN PATIENTS WITH ACUTE MYELOID LEUKEMIA
Journal: Indian Journal of Medical Research and Pharmaceutical Sciences (Vol.3, No. 5)Publication Date: 2016-05-30
Authors : Meram M. Bekhet; Nermeen TA Fouad; Hanaa Fathey; Eman El - Sayed; Laila M. Hendawy; Dina Khattab;
Page : 1-7
Keywords : AML; BAX gene; new molecular marker .;
Abstract
Searching for new molecular markers in acute myeloid leukemia (AML) that allow prediction of clinical outcome has recently directed towards genes involved in the regulation of apoptosis. Aim: To assess whether BAX gene expression per se is an independent p rognostic parameters for outcome in Egyptian patients with AML. Our case control study was conducted on fifty four subjects, thirty four adult de novo AML patients and twenty volunteers as a control group. All participants were subjected to medical history , thorough clinical examination and laboratory measuring of routine CBC and comprehensive metabolic profile . Quantitative real - time PCR for BAX was done for all subjects. BAX gene expression was detected in AML patients and there was a significant correlat ion between the patients and control group (p value< 0.001). The complete remission rate after first induction chemotherapy was seen in 15 patients (71.4%) with high BAX expression and in 6 patients with low BAX expression, while only 4 out of 13 (30.7%) w ith poor clinical outcome expressed high BAX gene levels. This should deduce that BAX, as a promoter of apoptosis, could act as a prognostic indicator in our sample of AML patients.
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