SIMULTANEOUS QUANTITATIVE ESTIMATION OF ETODOLAC AND PARACETAMOL IN TABLETS BY Q-ANALYSIS UV METHOD

The developed method uses 0.1 N NaOH as solvent for estimation of etodolac and paracetamol in tablets by Qanalysis method, at wavelengths of 224.22 nm and 257.14 nm. The method resulted in linearity in the range 1- 8μg/ml and 0.8125-6.5μg/ml for etodolac and paracetamol respectively. System precision and intra-day precision are determined. Percentage relative standard deviation are 1.36 and 0.25 for Etodolac, while 4.96 and 5.93 for Paracetamol. Method was found to be rugged as precision was found to be 3.5%, 5.63% for etodolac and paracetamol. Accuracy was performed and the values were found to be in the range of 90-110% by percentage method . Hence it can be concluded that, a cost effective assay method is developed and validated* which can be used in various pharmaceutical industries. Keywords: UV, Etodolac , Paracetamol, assay, Validation.