METHOD FOR OPTIMIZING HPLC FOR SEPARATING CARBAMAZEPINE AND IT’S IMPURITIES
Journal: IMPACT : International Journal of Research in Applied, Natural and Social Sciences ( IMPACT : IJRANSS ) (Vol.4, No. 4)Publication Date: 2013-04-23
Authors : ASHOK KUMAR; AMIT GUPTA; PRADEEP KUMAR; DEEPAK; . A.K.AGARWAL;
Page : 63-68
Keywords : Carbamazepine; Iminostilbene; Iminodibenzyl; HPLC;
- METHOD FOR OPTIMIZING HPLC FOR SEPARATING CARBAMAZEPINE AND IT’S IMPURITIES
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Abstract
A simple, sensitive, precise and accurate HPLC method for simultaneous separation of Carbamazepine, Iminostilbene and Iminodibenzyl was developed and validated by using different stationary phases, mobile phases, and temperature parameters. The chromatographic separation of the drug and two impurities was achieved on a C18 column by using Water : Acetonitrile (60 : 40) as mobile phase, where a reasonable resolution, better sensitivity and a faster analysis time was obtained. Cyano column is used as the most suitable column for further optimization for keeping overall goal of a better separation and faster analysis.
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