EVALUATION OF CARDIO PROTECTIVE EFFECT OF LINAGLIPTIN A NOVEL DPP-4 INHIBITOR IN NORMAL AND STREPTOZOTOCIN INDUCED TYPE-2 DIABETIC RATS BY ISCHEMIC REPERFUSION INJURY METHOD

Evaluation of the cardio protective effect of Linagliptin a novel DPP-4 inhibitor which is used for the treatment of diabetes mellitus by the method ischemic reperfusion injury in normal and streptozotocin induced rats. To evaluate the cardio protective effect of Linagliptin in normal and type 2 diabetic rats by ischemic reperfusion injury using the following parameters. Evaluation of percentage left ventricle necrosis. Estimation of tissue antioxidant parameters like SOD, Catalase and GSH. Estimation of blood parameters like SGOT, CK, CK-MB and LDH. The Cardio protective effect of Linagliptin (5 mg/kg bd.wt p.o) was observed in normal rats by comparing the percentage of necrosis of left ventricle with normal I/R group, by using Left descending coronary artery ligation. Microscopical examination of the left ventricle proves that the Lnagliptin having the cardio protective effect by protecting the myocytes against the oxidative stress. Finally Cardio protective effect of Linagliptin was noticed at acute levels of study. Keywords: Linagliptin, Diabetes mellitus, Cardio protective action, Left ventricle necrosis