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SIMULTANEOUS ESTIMATION OF NAPROXEN AND DOMPERIDONE USING UV SPECTROPHOTOMETRY IN TABLET DOSAGE FORM

Journal: Bulletin of Pharmaceutical Research (Vol.3, No. 2)

Publication Date:

Authors : ;

Page : 66-70

Keywords : Simultaneous equation method; Validation; Naproxen; Domperidone; UV spectrophotometry;

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Abstract

An accurate, specific and precise UV spectrophotometric method was developed for the simultaneous determination of naproxen (NAP) and domperidone (DOM) in tablet dosage form. The optimum conditions for the analysis of the drug were established. The maximum wavelength (λmax) was found to be 271 nm for NAP and 287 nm for DOM. The linearity of the proposed method was found in the range of 10-35 ?g/ml and 5-30 ?g/ml for NAP and DOM respectively. Calibration curves showed a linear relationship between the absorbance and concentration. The line equation for NAP y = 0.0222x - 0.0226 with r2 of 0.9999 and for DOM y = 0.0292x - 0.0149 with r2 of 0.9998 was obtained. Validation was performed as per ICH guidelines for linearity, accuracy, precision, LOD and LOQ. The LOD was found to be 0.0454 and 0.656 ?g/ml for NAP and DOM and the LOQ was found to be 0.151 and 2.18 ?g/ml for NAP and DOM respectively. The proposed method was simple, sensitive, precise, accurate, quick and useful for routine analysis of NAP and DOM in tablet formulations.

Last modified: 2013-09-08 18:46:30