SYNTHESIS OF BROMO AND CHLORO DERIVATIVES OF BAYLIS?HILLMAN ADDUCTS

We have successfully developed a short and simple protocol for the synthesis of bromo and chloro derivatives of Baylis?Hillman adducts derived from nitroolefins in good yields. This novel class of bromo and chloro derivatives can be utilized as building blocks for wide variety of organic compounds. The reason why nitroethene is unexplored may be due to its higher reactivity, which would lead to polymerization. Though various trisubstituted olefins derived from Baylis?Hillman adducts using acrylates, acrylonitrile, or methyl vinyl ketone have been successfully nthesized and utilized for various organic transformations.