STUDY THE EFFECT OF OXIDATIVE STRESS AND SEVERAL BIOCHEMICAL FEATURES IN PATIENTS WITH HELICOBACTER PYLORI (H PYLORI) BACTERIA

Objective: Gastric ulcer, also known as peptic ulcer, is a localized area of erosion in the stomach lining, resultin abdominal pain, possible bleeding, and other gastrointestinal symptoms. The most common cause of gastric ulcer is a stomach infection associated with the Helicobacter pylori (H pylori) bacteria. The spread of H pylori among humans is not completely understood; it may spread through contaminated food and water. Antioxidants are molecules which can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged. The aim of the current study is to investigate the oxidative stress in patients with H. pylori and compare to control group. Methods: A total of 60 males were studied in Digestive Centerand Central Health Laboratory, Baghdad, Iraq. The samples were collected within 3 months, starting from July till September 2011. The pepsinogen I(PGI), pepsinogen II(PGII), Anti-Helicobacter pyloriIgG and gastrin 17 in sera of patients and control are measurement after subjected all patients for clinical diagnosis and examination of (gastroscopic) under the supervision of a committee of doctors jurisdiction. Laboratory investigations including gastric panel tests, serum total antioxidant capacity (TAA), malondialdehyde (MDA), Glutathione (GSH), Vitamin C, Vtamin E, uric acid and TAA / MDA ratio . The control group consisted of 40 healthy individuals who were not complaining of any gastro intestinal problem.