Phytochemical and anticarcinogenic evaluation of triphala powder extract, against melanoma cell line induced skin cancer in rats

Objective: Triphala is a botanical preparation consists of Terminalia chebula, Emblica officinalis, Terminalia bellerica and it exhibits a number of health benefits, including antioxidant activity, lowers cholesterol, inhibits HIV, Reduces tumors in animals, protects and improves liver function and many more. Triphala (Harad, Bahada and Amala) in different ratios exhibits a number of health benefits, including: anti-cancerous, antipyretic, antiulcer, antidiabetic activities. Triphala has historically been used as a digestive aid for constipation. Triphala triggered the cancerous cells to die off and significantly reduced the size of the tumours. This study was carried out to evaluate the effect of triphala powder (hydro alcoholic extract) on melanoma skin cancer in rats.Methods: The study was carried out on the melanoma cell line (B6F10) induce model.Results: The powder extract of triphala produced a significant activity in Melanoma cell line-induced skin cancer.Conclusions: Triphala extract increased healing of melanoma skin cancer and prevented the development of experimentally induced skin cancer in rats.