Ethiopathogenetic Factors of Precancerous Gynecological Diseases in Patients with Breast Cancer

The objective of the research was to assess risk factors for precancerous gynecological disease (PGD) in patients with breast cancer (BC) after comprehensive and combination treatment.Materials and methods. The study was based on the results of examination and treatment of 40 patients suffering from BC with PGD which developed at different times after treatment. In patients with breast cancer PGD included precancerous uterine body disease in 26 (65.0 %) patients, the precancerous ovariopathies in 9 (22.5 %) individuals and precancerous cervical disease in 5 (12.5%) cases.Results of the research. Precancerous uterine body disease occurred most often in most patients with BC after treatment. It included atypical endometrial hyperplasia in 19 (73.0%) patients and proliferating nodular leiomyoma of uterine body in 7 (27.0%) cases. Precancerous ovariopathies detected in patients with BC included allied papillary mucinous cystadenoma of ovaries in 6 (66.7%) patients and endometrioid cystadenoma in 3 (33.3%) cases. Precancerous cervical disease detected in patients with BC included severe cervical intraepithelial neoplasia (CIN III). CIN III was found in 5 (12.5%) cases. Conclusions. According to the results of the analysis and literature data, PGD occurred in patients with BC. The results indicated that hormonal factors, burdened oncology case history and results of immunohistochemical and molecular genetic diagnosis of breast tumors are important in PGD development in patients with BC.