Ibuprofen induced neutropenia manifesting as oral ulcerations

Abstract Oral ulcerations of varied etiology are commonly seen in dental practice. Among all the causes of oral ulcers, those due to neutropenia are significant. Neutropenia can occur in many systemic conditions and also in patients on long-term therapy of certain drugs like Ibuprofen. Here, we report a case of a 40-year-old female patient who developed oral ulcerations secondary to Ibuprofen -induced neutropenia. Early diagnosis of the condition led to discontinuation of the offending drug and significant improvement in her blood picture and also prevented many other complications including systemic infections that neutropenia can cause.