Determination of Paracetamol and Ibuprofen in Tablets and Urine Using Spectrofluorimetric Determination Coupled with Chemometric Tools

It was developed a methodology for spectrofluorimetric determination of Paracetamol (PAR) and Ibuprofen (IBU) in tablets (synthetic mixtures) and biological fluids (urine) coupled with chemometrics. For tablet’s determination, it was used PLS (Partial Least Squares) and for urine samples it was used PARAFAC (Parallel Factor Analysis). In both cases, it was possible to quantify both analytes in samples. The proposed methodology showed effectiveness and offered excellent results in the determination of PAR and IBU. Recovery study test was performed in urine samples, and it offered good results also. Figures of merit were established.