Analytical Techniques in Simultaneous Estimation: An Overview

Simultaneous estimation plays a very important role in pharmaceutical world as it is very feasible and time saving. For the multi component analysis various techniques like spectrophotometric techniques (UV-VIS, IR, NMR and MASS spectrometry) and chromatographic techniques (Thin Layer Chromatography, High Performance Liquid Chromatography, Ultra-High Performance Liquid Chromatography, High Pressure Thin Layer Chromatography and Gas Chromatography) is used. These techniques provide high degree of specificity and selectivity and further provide the high degree of assurance that these techniques fit for the simultaneous estimation of the pharmaceutical dosage form. Chromatographic and spectrophotometric techniques together develop new hyphenated techniques which are useful for the simultaneous estimation and impurity profiling. The simultaneous analytical analysis provides specificity and assurance for the identification of the chemical entities in the pharmaceutical formulation. The main objective behind the analytical estimation is to provide the assurance that the particular formulation contains the equal amount of active pharmaceutical ingredient as mentioned in the label.