DESIGN, SYNTHESIS, CHARACTERIZATION OF SOME NEW SUBSTITUTED CHALCONES AND STUDIES THEIR ANTIMICROBIAL ACTIVITIES

Eight designed chalcones, named [1(p - benzenesulphonamidophenyl) - 3 - p - chloro - 2 - propene - 1 - one][2], [1(p - benzenesulphonamidophenyl) - 3 - p - nitro - 2 - propene - 1 - one][3], [1(4 - Ureido)phenyl - 3 - p - chlorophenyl - 2 - propene - 1 - one][5], [1(4 - Ureido)phenyl - 3 - p - nitroophenyl - 2 - propene - 1 - one][6], [1(4(p - N - methyl aminophenyl)azophenyl - 3 - p - chlorophenyl - 2 - propene - 1 - one][8], [1(4(p - N - methylaminophenyl)azophenyl - 3 - p - nitroophenyl - 2 - propene - 1 - one][9], [1(p - aminophenyl) - 3 - p - chlorophenyl - 2 - propene - 1 - one][10] and [1(p - aminophenyl) - 3 - p - nitrophenyl - 2 - propene - 1 - one][11], were synthesised by condensation of synthesised p - acetylphenylbenzene - sulphonamide, p - acetylphenylurea and p - acetyl - p' - (N - methylamino)azobe nzene, with p - chlorobenzaldehyde and p nitrobenzaldehy de in basic media respectively. All synthesised compounds are char acterized by its melting points, FTIR, 1H NMR, 13C NMR and Mass spectral analysis. All synthesised compounds are examined their antimicrobial activities against Gram - Ve bactria (Serratia marcescens, Pseudmonas aeroginosa) and Gram+Ve bacterial (Stphylococ cus aureus, Streptococcus pyogenes), and Candida albicans fungi. Result showed good to moderate inhibition effect against some bacteria and fungi, in comparison with some pharmaceutical antibiotic and antifungal treatments like Cephalexin, Amoxicillin, Tetracycline, Lincomycine, Nystatine and Fluconazole respectively.