Antimicrobial Resistance in P. aeruginosa - A Review

Pseudomonas aeruginosa, which is intrinsically resistant to a number of antimicrobial agents, is a leading cause of Gram negative hospital acquired infections. P. aeruginosa, in hospitalized patients, has the ability to develop multidrug resistance posing serious therapeutic problems and increases the mortality rate associated with its infection. Resistance to most antipseudomonal agents has increased by >20%, over the last five years. Many antibiotics inhibit the growth of P. aeruginosa to some extent in vitro, but only few of them show useful activity at therapeutically attainable concentrations. This review is aimed to discuss about the different groups of potential antipseudomonal agents such as antipseudomonal penicillins, cephalosporins, aminoglycosides, fluroquinolones, carbapenems, etc. and their resistance mechanisms.