Genetic polymorphisms in the promoter region of catalase gene, creates new potential PAX-6 and STAT4 response elementsJournal: Molecular Biology Research Communications (Vol.5, No. 2)
Publication Date: 2016-06-01
Authors : Khyber Saify;
Page : 97-100
Keywords : Catalase; PAX-6; STAT4; Transcription factors;
Catalase (CAT, OMIM: 115500) is an endogenous antioxidant enzyme and genetic variations in the regulatory regions of the CAT gene may alter the CAT enzyme activity and subsequently may alter the risk of oxidative stress related disease. In this study, potential influence(s) of the A-21T (rs7943316) and C-262T (rs1001179) genetic polymorphisms in the CAT promoter region, using the ALGGEN-PROMO.v8.3 online software were analyzed. Our findings show that the A allele at the -21 position creates a new potential binding site for PAX-6 and the T allele at the -262 position changes the TFII-I binding site into STAT4 response element. The PAX-6 and STAT4 are the multifunctional and enhancing transcription factors.
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