Coexistence of Monoclonal Gammopathy of Undetermined Significance with Essential Thrombocythemia

We found an interesting case about the patient coexistence of monoclonal gammopathy of undetermined significance (MGUS) and essential thrombocythemia (ET). After this patient has been diagnosised essential thrombocythemia five years, he suffered hyperglobulinemia. We analysis the relationship of this two diseases and review. It is known that the IL-6 can stimulate megakaryocyte proliferation in vitro and raise the counts of platelet in vivo, but pathogenesis of the two diseases about whether have the same common cellular origins needs to be explored. Coexistence of monoclonal gammopathy of undetermined significance with essential thrombocythemia in the same patient is rare and we believe that this study is of interest to us.