DESIGN AND IN-VITRO EVALUATION OF PREDNISOLONE MUCOADHESIVE TABLETS FOR COLON TARGETED DRUG DELIVERY SYSTEM
Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.3, No. 06)Publication Date: 2016-06-19
Authors : V. Jayasankar Reddy; G.Sindhu;
Page : 613-618
Keywords : Prednisolone; Mucoadhesive; PVP; Pectin; Ex-vivo; In-vitro.;
Abstract
The study was designed to develop mucoadhesive tablets of using PVP and Pectin inter polymer complexes and to systematically evaluate their in-vitro and ex-vivo performances. Prednisolone is a synthetic glucocorticoid, a derivative of cortisol, which is used to treat a variety of inflammatory and auto-immune conditions. Colon targeted drug delivery is an active area of research for local diseases affecting the colon, as it improves the efficacy of therapeutics and enables localized treatment, which reduces systemic toxicity. Targeted delivery of therapeutics to the colon is particularly advantageous for the treatment of inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease. Mucoadhesive tables were prepared by direct compression method. The physicochemical interaction between PVP and Pectin was investigated by FTIR studies. Tablets were evaluated their compatibility studies by using FT-IR, micrometrics properties, post formulation characters such as hardness, thickness, friability, content uniformity, Ex vivo mucoadhesive strength and in-vitro dissolution studies. Key Words: Prednisolone, Mucoadhesive, PVP, Pectin, Ex-vivo, In-vitro.
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