Gefitinib and Dermal Reaction: Uncovering the Path of Management

Gefitinib induced skin reactions especially acneiform and vesiculo-bullous pustular lesion are very common particularly in summer season or the area where climate temperature is towards the higher side. Almost 50% of the patients, who take Gefitinib, develop dermal reactions. Gefitinib induced acne may be related to excessive follicular hyperkeratosis, obstructions of the follicular ostium, follicular plugging and alteration of hair cycle progression, which lead to an inflammatory response. Here, we explored different treatment possibilities for the management of these types of cutaneous reactions and also the recommendations for the use of Gefitinib therapy. Multidisciplinary treatment approach in the form of oral antibiotics and topical application with proper education to the patient to prevent or manage the dermatological reactions in patients who are treated with Gefitinib are essential in order to minimize the negative likelihood of treatment disruptions or modifications.