RESPONSE OF EXERCISE TRAINING ON HIGH DENSITY LIPOPROTEINCHOLESTEROL AND ITS SUBFRACTIONS

Lipoprotein abnormalities play a major role in the development and progression of atherosclerotic cardiovascular disease. Low level of HDL-C is an important independent risk factor for atherosclerotic cardiovascular disease1 . HDL-C levels can be modified by exercise training2 . This is because of various enzymes involved in HDL metabolism and the interaction of that with physical activity 2-8 . Endothelial lipase is one such enzyme which has high phospholipase A1 activity and hydrolyzes HDL2 phospholipds to free fatty acids and lysophosphatidylcholine converting it to HDL39 . The beneficial effect of exercise training on increasing the levels of HDL-C and its subfractions are linked to endothelial lipase enzyme involved in HDL metabolism. This study aims to find out the response of exercise training on HDL cholesterol and its subfraction levels. 60 apparently healthy subjects of 30-65 years of age who are newly enrolled in a fitness centre was selected for the study. Subjects with history of smoking, hypertension, diabetes mellitus, BMI > 35 kg/m2 and any other acute or chronic illness are excluded. Baseline assessment of, Fasting cholesterol, Fasting HDL2 and HDL3 subfraction was performed. After 24 weeks of exercise training, Fasting cholesterol and Fasting HDL2 and HDL3 subfractions was done for 51 subjects. Nine subjects were irregular in attending exercise training and also discontinued from fitness centre, so were excluded from the study. Total cholesterol, total HDL cholesterol , HDL 3 subfraction , HDL 2 subfraction and total cholesterol/HDL ratio showed statistically significant difference between baseline data and data after exercise training. There was a beneficial effect of exercise training on High density lipoprotein cholesterol and its subfraction levels and was explined by endothelial lipase enzyme involved in HDL-C metabolism