STUDIES ON BIOCHEMICAL PROFILES OF DOGS AFTER EPIDURAL KETAMINE ALONE AND IN COMBINATION WITH PENTAZOCINE OR MEPERIDINE

Fifteen clinically healthy mongrel dogs of either sex of about one year of age were randomly divided in to three groups containing five dogs in each. The ketamine hydrochloride was administered epidurally at lumbosacral space in group I, whereas pentazocine and meperidine hydrochloride were given epidurally in combination with ketamine hydrochloride in group II and III, respectively. AST, ALT, glucose and creatinine showed a significant variation within normal physiological limits; whereas, GGT, BUN and total protein did not showed a significant variation (P>0.05) at respective intervals of observation. It may be concluded that epidural administration of ketamine in combination of opioids are safe and did not produce deleterious effect on vital organs.