AN INTERESTING CASE OF JAUNDICE

Overlap syndrome is used to describe variant forms of autoimmune hepatitis (AIH) which present with characteristics of AIH and primary biliary cirrhosis (PBC) or primary sclerosing cholangitis (PSC). Patients with overlap syndromes present with both hepatitic and cholestatic serum liver tests and have histological features of AIH and PBC or PSC. AIH-PBC is the most common form of overlap syndrome, affecting almost 10 of adults with AIH or PBC. Overlap syndromes show a progressive course without treatment, and therapy is empiric. Ursodeoxycholic acid is usuallycombined with immunosuppressive therapy but end-stage disease requires liver transplantation. We report a case of AIH-PBC overlap syndrome presenting with jaundice.