Paroxysmal Kinesigenic Dyskinesia: A Rare Neurological Disorder Posing Diagnostic Challenge but Therapeutic Rewards

Background: Paroxysmal kinesigenic dyskinesia (PKD) is one of the rare hyperkinetic movement disorder, characterized by brief, episodic hyperkinetic movement abnormalities like dystonia, chorea, hemiballismus or a combination, usually precipitated by sudden body movements, e.g. running, walking, standing, turning in bed, etc., lasting usually for a few seconds and followed by a variable period of refractoriness. By rule, consciousness is preserved and it usually responds well to antiepileptic drugs (AEDs). Objective: To report clinical and demographic profiles of a series of three cases of sporadic PKD. Observation: Three cases of idiopathic PKD, all male, two of them had onset in the second decade and one in the third decade, without a family history, with variable phenomenology, duration and precipitants but with remarkable response to carbamazepine. Conclusion: A high index of suspicion should be maintained as diagnosis of PKD is largely clinical and accurate diagnosis is rewarded with remarkable therapeutic response with AEDs.