Phosphodiesterase as a Drug Target of Alzheimer’s Disease

Although amyloid hypothesis is widely accepted, recent findings indicate that the hypothesis may be incorrect, suggesting that Aβ is not a suitable drug target in Alzheimer’s disease. Accumulating evidences and new findings suggest that phosphodiesterases is involved in Alzheimer’s disease. In this review, I introduce the current state of phosphodiesterases and their inhibitors as for Alzheimer’s research.